Brief Report: Factor VIII (AHF) Concentration in pH 6.5 Citrate-Plasma

Effects of plasmin on human factor VIII (AHF).

Highly purified, fibrinogen-free human gel electrophoresis. The split products factor VIII was incubated with plasmin, were not anticoagulant in the factor and the liberated split products of the VIII activity assay. In fact, the breakfactor VIII were analyzed by gel filtradown products in the hydrolysate intion, acrylamide gel electrophoresis, creased the factor VIII activity of bioassay, and ...

Immunologic studies of antihemophilic factor (AHF, factor VIII). V. Immunologic properties of AHF subunits produced by salt dissociation.

Fainting induces an acute increase in the concentration of plasma factor VIII and von Willebrand factor.

BACKGROUND AND OBJECTIVES von Willebrand factor (VWF) is stored in the Weibel-Palade bodies of endothelial cells and may be released in response to different secretion stimuli such as stress, physical exercise, adrenaline, DDAVP and thrombin. DESIGN AND METHODS We found that fainting can also induce an acute increase in plasma VWF and factor FVIII (FVIII) concentrations, following observation...

Familial association of thrombopathia and antihemophilic factor (AHF, factor VIII) deficiency.

Five female members of a family manifesting a dominantly inherited bleeding disorder were investigated for coagulation and platelet abnormalities. A long bleeding time, mild thrombocytopenia, large platelets, low platelet factor-3 activity (PF-3), and low factor VIII levels were found in the proband. Long bleeding times, low PF-3, and low factor VIII levels were found in various combinations in...

Possible effect of secretor locus on plasma concentration of factor VIII and von Willebrand factor.

A significant fraction (30%) of the genetically determined variance in plasma concentration of the von Willebrand factor antigen (vWf:Ag) has been shown to be related to ABH determinants. Individuals with blood group O, who have the highest amounts of blood group H substance, have the lowest concentration of vWf:Ag. The Lewis substances, Le(a) and Le(b), are biochemically closely related to the...